Kaplan Nursing Entrance Practice Exam

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Who first articulated the central dogma of molecular biology?

James Watson
Francis Crick
Charles Darwin
Gregory Mendel

The correct answer is: Francis Crick

The central dogma of molecular biology, which describes the flow of genetic information from DNA to RNA to protein, was primarily articulated by Francis Crick in a seminal paper published in 1957. Crick’s formulation emphasized how genetic information is transferred and expressed within biological systems, establishing a framework for understanding molecular genetics. While James Watson, who co-discovered the structure of DNA alongside Crick, contributed significantly to the field of molecular biology, the specific phrase "central dogma" and its precise conceptualization are attributed to Crick. Charles Darwin and Gregory Mendel made foundational contributions to the fields of evolution and genetics, respectively, but their work did not directly address the molecular processes described by the central dogma.